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Medchemexpress LLC Anti-Mouse IL-9 Anti 10mg | 10mg
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Anti-Mouse IL-9 Antibody (9C1) is an anti-mouse IL-9 IgG2a monoclonal antibody Anti-Mouse IL-9 Antibody (9C1) can reduce the activation of NF- B signaling pathway and decrease the infiltration of inflammatory cells Anti-Mouse IL-9 Antibody (9C1) effectively reduces Th9 cell-mediated allergic reactions and anti-tumor effects Anti-Mouse IL-9 Antibody (9C1) can be used for researches on inflammation infection conditions and cancer such as parasitic infections allergic reactions breast cancer and osteosarcoma[1][2][3][4]
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![Medchemexpress LLC (1S,5S)-3-Oxabicyclo[3.1.0]hexan-1-amine hydrochloride | 2968348-02-7 | 102.8% | 135.59 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403917-logo.png-250.jpg){kind=logo}
Medchemexpress LLC (1S,5S)-3-Oxabicyclo[3.1.0]hexan-1-amine hydrochloride | 2968348-02-7 | 102.8% | 135.59 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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(1S,5S)-3-Oxabicyclo[3.1.0]hexan-1-amine hydrochloride is a drug intermediate for the synthesis of various active compounds.
- Used as a drug intermediate
- Synthesizes various active compounds
- For research use only
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Medchemexpress LLC Iseganan | 257277-05-7 | 98.9% | 1900.28 | 5 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Iseganan is an anti-microbial peptide active against Gram-positive and Gram-negative bacteria and fungi. It kills a broad spectrum of bacteria and fungi by attaching to and destroying the integrity of lipid cell membranes. This peptide can be used for oral mucositis research.
- Active against Gram-positive and Gram-negative bacteria and fungi
- Disrupts T. crassiceps cysticerci in vitro
- Shows anti-parasite activity in T. crassiceps murine cysticercosis model
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Medchemexpress LLC PBRM1-BD2-IN-2 | 2819989-57-4 | C14H9Cl2FN2O | 1 MG
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PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. It demonstrates binding affinity and inhibitory activity for PBRM1-BD2, making it suitable for cancer research. This compound selectively inhibits the growth of PBRM1-dependent prostate cancer cell lines.
- Selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor
- Has binding affinity for PBRM1-BD2 with Kd of 9.3 μM
- Shows inhibitory activity for PBRM1-BD2 with IC50 of 1.0 μM
- Useful for cancer research
- Selectively inhibits the growth of PBRM1-dependent prostate cancer cell lines
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Medchemexpress LLC Guanylyl Cyclase alpha 1 antibody (YA2937) | 10 UL
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Guanylyl Cyclase alpha 1 Antibody (YA2937) is a recombinant, monoclonal, Rabbit-derived IgG antibody designed for research use. This non-conjugated antibody targets Guanylyl Cyclase alpha 1 and is supplied as a liquid formulation.
- Targets Guanylyl Cyclase alpha 1
- Rabbit-derived IgG monoclonal antibody
- Affinity purified
- Non-conjugated
- Suitable for Western Blot (WB) applications
- Reacts with human samples
- Subcellular localization in cytoplasm
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Medchemexpress LLC DHPS-IN-1 100mg | 2643300-54-1 | 406.66 g/mol | C17H13BrClN3O2 | 100 MG
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DHPS-IN-1 is a potent small-molecule inhibitor of deoxyhypusine synthase (DHPS) with demonstrated cellular activity against melanoma cell lines. The compound features a low nanomolar DHPS inhibitory potency and is supplied at high purity for research applications, with available solid and solution formats suited to in vitro and in vivo studies.
- Potent DHPS inhibitor (IC50 = 0.014 μM).
- Demonstrates cytotoxicity against melanoma cell lines.
- High reported purity (99.78%).
- Available in multiple pack sizes and as a 10 mM DMSO solution for convenience.
- Good DMSO solubility (≈86.67 mg/mL) with recommended animal dosing vehicles.
- Store at -20°C, protect from light; solutions stable at -80°C for extended storage.
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Medchemexpress LLC HP211206 | 3119106-17-8 | 883.94 | 1 MG
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HP211206 is a SARS-CoV-2 main protease (Mpro) PROTAC degrader. It effectively degrades SARS-CoV-2 Mpro and its drug-resistant mutants. It exhibits an IC50 of 181.9 nM and a DC50 of 621 nM for Mpro, and it also possesses antiviral activity. The compound is composed of H117 (HY-170599) in pink, a linker (HY-B0236) in black, and an E3 ligase ligand (HY-41547) in blue.
- SARS-CoV-2 Mpro PROTAC degrader.
- Effectively degrades SARS-CoV-2 Mpro and its drug-resistant mutants.
- Has an IC50 of 181.9 nM for Mpro.
- Has a DC50 of 621 nM for Mpro.
- Exhibits antiviral activity.
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Medchemexpress LLC Laroprovstat (AZD0780) | 2455427-91-3 | 99.9% | 414.41 | 50 MG
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Laroprovstat (AZD0780) is an orally active PCSK9 inhibitor. It has a binding affinity for PCSK9 with a Kd value of <200 nM. Laroprovstat binds to a pocket in the PCSK9 C-terminal domain without affecting the PCSK9-LDL receptor (LDLR) interaction. It inhibits the lysosomal trafficking of PSCK9-LDLR complexes and prevents PCSK9-induced LDLR degradation. It is used for the research of hypercholesterolemia.
- Orally active PCSK9 inhibitor
- High binding affinity for PCSK9 (Kd <200 nM)
- Inhibits lysosomal trafficking of PSCK9-LDLR complexes
- Prevents PCSK9-induced LDLR degradation
- Potential for hypercholesterolemia research
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Medchemexpress LLC Exodus-2/CCL21 Huma 100ug
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Recombinant human CCL21 (Exodus-2), corresponding to residues S24-P134, supplied lyophilized for use in bioactivity assays such as chemotaxis. The protein is expressed in E. coli, demonstrates >95% purity by reducing SDS-PAGE, and shows chemotactic activity on human lymphocytes with an ED50 of 11.61 ng/mL.
- Provided as lyophilized powder for long-term storage.
- Contains residues S24-P134 of human CCL21.
- Expressed in E. coli for recombinant production.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Demonstrated chemotactic activity at 10-100 ng/mL (ED50 11.61 ng/mL).
- Lyophilized formulation: 20 mM PB, 150 mM NaCl, pH 7.4.
- Store lyophilized at -20°C; aliquot and freeze at -20°C or -80°C after reconstitution.
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Medchemexpress LLC envelope glycoprotei 50ug
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envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope Gp120 is essential for viral infection as it facilitates HIV entry into the host cell gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus envelope glycoprotein gp120 Protein HIV-1 (AAA44191 HEK293 His) is the recombinant Virus-derived envelope glycoprotein gp120 protein expressed by HEK293 with C-10 His labeled tag
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Medchemexpress LLC 24R-Calcipotriol | 112827-99-3 | C27H40O3 | 1 MG
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24R-Calcipotriol (PRI 2202) is an impurity of Calcipotriol, a ligand of VDR-like receptors and a Vitamin D3 analog. It displays minimal effects on calcium homeostasis and regulates cell differentiation and proliferation.
- Exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines.
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Medchemexpress LLC IL-21R Mouse HEK29 100ug
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The IL-21R protein is specifically designed for IL-21 and forms a heterodimeric complex with the common subunit which is critical for signal transduction This receptor complex promotes interaction with Janus kinase 1 (JAK1) initiating downstream signaling events in response to interleukin-21 IL-21R Protein Mouse (HEK293 Fc) is the recombinant mouse-derived IL-21R protein expressed by HEK293 with C-hFc labeled tag
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Medchemexpress LLC RO6806051 | 1433901-75-7 | 99.84% | 390.87 | 50 MG
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RO6806051 is a selective FABP4 and FABP5 inhibitor for research of inflammation-related diseases. It is a potent dual inhibitor of purified human hFABP4 and hFABP5, showing approximately 209-fold selectivity for hFABP4 over hFABP3 and about 27-fold selectivity for hFABP5 over hFABP3.
- Selective FABP4 and FABP5 inhibitor
- Human FABP4 Ki values of 0.011 μM and 0.23 μM
- Human FABP5 Ki values of 0.086 μM and 1.17 μM
- Suitable for research of inflammation-related diseases
- Exhibits favorable physicochemical properties
- Low liver microsomal clearance in human and mouse
- Weak to no inhibition of major cytochrome P450 enzymes
- Shows significant cytotoxicity against differentiated THP-1 macrophages at concentrations of 20 μM and above
- Moderately inhibits MCP-1 secretion in LPS-stimulated THP-1 macrophages
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Medchemexpress LLC MMP-9-IN-6 | 2241964-36-1 | 99.8% | 365.42 | 25 MG
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MMP-9-IN-6 (Compound 3g) is an MMP-9 inhibitor with an IC50 value of 50 μM, demonstrating a good anti-ulcer effect. This product is for research use only and is not sold to patients.
- MMP-9 inhibitor
- IC50 value of 50 μM
- Demonstrates good anti-ulcer effect
- Purity of 99.8%
- Solid appearance
- Color is pale purple to purple
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Medchemexpress LLC Rezetecán (SHR9265) | 99.6% | 1195.27 | 1 MG
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Rezetecán (SHR9265) is a topoisomerase I inhibitor that can be used to synthesize Trastuzumab rezetecan, an antineoplastic agent. It also functions as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs).
- Topoisomerase I inhibitor
- Used to synthesize Trastuzumab rezetecan, an antineoplastic agent
- Functions as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)
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